Jon's Health Tips: Dark Chocolate

Dark chocolate: Half a bar per week to keep at bay the risk of heart attack

An Italian study, the first outcome of a large epidemiological investigation, finds new beneficial effects of chocolate in the prevention of cardiovascular disease

6.7 grams of chocolate per day represent the ideal amount for a protective effect against inflammation and subsequent cardiovascular disease.

The findings, published in the last issue of the Journal of Nutrition, official journal of the American Society of Nutrition, come from one of the largest epidemiological studies ever conducted in Europe, the Moli-sani Project, which has enrolled 20,000 inhabitants of the Molise region so far. By studying the participants recruited, researchers focused on the complex mechanism of inflammation. It is known how a chronic inflammatory state represents a risk factor for the development of cardiovascular disease, from myocardial infarction to stroke, just to mention the major diseases. Keeping the inflammation process under control has become a major issue for prevention programs and C reactive protein turned out to be one of the most promising markers, detectable by a simple blood test.

"We started from the hypothesis- says Romina di Giuseppe, 33, lead author of the study- that high amounts of antioxidants contained in the cocoa seeds, in particular flavonoids and other kinds of poly-phenols, might have beneficial effects on the inflammatory state. Our results have been absolutely encouraging: people having moderate amounts of dark chocolate regularly have significantly lower levels of C-reactive protein in their blood. In other words, their inflammatory state is considerably reduced." The 17% average reduction observed may appear quite small, but it is enough to decrease the risk of cardiovascular disease for one third in women and one fourth in men. It is undoubtedly a remarkable outcome".
Chocolate amounts are critical. "We are talking of a moderate consumption. The best effect is obtained by consuming an average amount of 6.7 grams of chocolate per day, corresponding to a small square of chocolate twice or three times a week. Beyond these amounts the beneficial effect tends to disappear".

From a practical point of view, as the common chocolate bar is 100 grams, the study states that less than half a bar of dark chocolate consumed during the week may become a healthy habit. What about the milk chocolate? "Previous studies- the young investigator continues- have demonstrated that milk interferes with the absorption of polyphenols. That is why our study considered just the dark chocolate".

Researchers wanted to sweep all the doubts away. They took into account that chocolate lovers might consume other healthy food too, as wine, fruits and vegetables. Or they might exercise more than others people do. So the observed positive effect might be ascribed to other factors but not to cocoa itself. "In order to avoid this - researcher says - we "adjusted" for all possible "confounding" parameters. But the beneficial effect of chocolate still remained and we do believe it is real".

Resveratrol, red wine compound linked to health, also found in dark chocolate and cocoa.

The levels of resveratrol found in cocoa and chocolate products is second to red wine among known sources of resveratrol and forms yet another important link between the antioxidants found in cocoa and dark chocolate to other foods.

"Cocoa is a highly complex natural food which contains in excess of seven hundred naturally occurring compounds, with many more yet to be discovered," explains Jeff Hurst, the lead chemist on the project. "For years, flavanols, a different class of compounds in chocolate, received most of the attention, but these are quite different than resveratrol. It is exciting to see additional antioxidants identified in cocoa and chocolate."

The results of the survey show that cocoa powder, baking chocolate and dark chocolate contain on average 14.1 to 18.5 micrograms of resveratrol per serving while the level found in the average California red wine is 832 micrograms per glass. Roasted peanuts have an average of 1.5 micrograms and peanut butter, 13.6 micrograms of resveratrol per serving: demonstrating that cocoa and dark chocolates are meaningful sources of resveratrol in the US diet.

Consumption of small amounts of dark chocolate associated with reduction in blood pressure

Eating about 30 calories a day of dark chocolate was associated with a lowering of blood pressure, without weight gain or other adverse effect.

Previous research has indicated that consumption of high amounts of cocoa-containing foods can lower blood pressure (BP), believed to be due to the action of the cocoa polyphenols (a group of chemical substances found in plants, some of which, such as the flavanols, are believed to be beneficial to health). “A particular concern is that the potential BP reduction contributed by the flavanols could be offset by the high sugar, fat and calorie intake with the cocoa products,” the authors write. The effect of low cocoa intake on BP is unclear.

Dirk Taubert, M.D., Ph.D., of University Hospital of Cologne, Germany, and colleagues assessed the effects of low regular amounts of cocoa on BP. The trial, conducted between January 2005 and December 2006, included 44 adults (age 56 through 73 years; 24 women, 20 men) with untreated upper-range prehypertension (BP 130/85 – 139/89) or stage 1 hypertension (BP 140/90 – 160/100). Participants were randomly assigned to receive for 18 weeks either 6.3 g (30 calories) per day of dark chocolate containing 30 mg polyphenols or matching polyphenol-free white chocolate.

The researchers found that from baseline to 18 weeks, dark chocolate intake reduced average systolic BP by _2.9 (1.6) mm Hg and diastolic BP by _1.9 (1.0) mm Hg without changes in body weight, plasma levels of lipids or glucose. Hypertension prevalence declined from 86 percent to 68 percent. Systolic and diastolic BP remained unchanged throughout the treatment period among those in the white chocolate group.

“Although the magnitude of the BP reduction was small, the effects are clinically noteworthy. On a population basis, it has been estimated that a 3-mm Hg reduction in systolic BP would reduce the relative risk of stroke mortality by 8 percent, of coronary artery disease mortality by 5 percent, and of all-cause mortality by 4 percent,” the authors write.

“The most intriguing finding of this study is that small amounts of commercial cocoa confectionary convey a similar BP-lowering potential compared with comprehensive dietary modifications that have proven efficacy to reduce cardiovascular event rate. Whereas long-term adherence to complex behavioral changes is often low and requires continuous counseling, adoption of small amounts of flavanol-rich cocoa into the habitual diet is a dietary modification that is easy to adhere to and therefore may be a promising behavioral approach to lower blood pressure in individuals with above-optimal blood pressure. Future studies should evaluate the effects of dark chocolate in other populations and evaluate long-term outcomes,” the authors conclude.

Cocoa Health Benefits

Norman Hollenberg, professor of medicine at Harvard Medical School has spent years studying the benefits of cocoa drinking on the Kuna people in Panama. He found that the risk of 4 of the 5 most common killer diseases: stroke, heart failure, cancer and diabetes, is reduced to less then 10% in the Kuna. They can drink up to 40 cups of cocoa a week. Natural cocoa has high levels of epicatechin.

'If these observations predict the future, then we can say without blushing that they are among the most important observations in the history of medicine,' Hollenberg says. ‘We all agree that penicillin and anaesthesia are enormously important. But epicatechin could potentially get rid of 4 of the 5 most common diseases in the western world, how important does that make epicatechin?... I would say very important’

Nutrition expert Daniel Fabricant says that Hollenberg’s results, although observational, are so impressive that they may even warrant a rethink of how vitamins are defined. Epicatechin does not currently meet the criteria. Vitamins are defined as essential to the normal functioning, metabolism, regulation and growth of cells and deficiency is usually linked to disease. At the moment, the science does not support epicatechin having an essential role. But, Fabricant, who is vice president scientific affairs at the Natural Products Association, says: 'the link between high epicatechin consumption and a decreased risk of killer disease is so striking, it should be investigated further. It may be that these diseases are the result of epicatechin deficiency,' he says.

Epicatechin is also found in teas, wine, chocolate and some fruit and vegetables.

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Jon's Health Tips: Eating Fish

Eating Fish

I eat a lot of fish – mostly salmon, but lots of other fish as well. However, I avoid swordfish and tuna, especially tuna steaks and albacore because of high levels of mercury, and tilapia because of high levels of omega-6. I eat fish because its healthy and I like it, and when I’m eating fish I’m not eating meat. I supplement my fish consumption with fish oil or flaxseed oil on days that I do eat meat.
My daughter, who is a pediatrician and vegetarian, also uses flaxseed oil and gives her 3 children fish oil supplements.

Here’s why:

Fish reduces asthma and allergies
Giving children a diet rich in fish and “fruity vegetables” can reduce asthma and allergies, according to a seven-year study of 460 Spanish children, published in the September issue of Pediatric Allergy and Immunology.
The findings also reinforce the researchers’ earlier findings that a fish-rich diet in pregnancy can help to protect children from asthma and allergies.
Eating fish may explain very low levels of heart disease in Japan
Consuming large quantities of fish loaded with omega-3 fatty acids may explain low levels of heart disease in Japan, according to a study led by the University of Pittsburgh Graduate School of Public Health slated for the Aug. 5 issue of the Journal of the American College of Cardiology and available online. The study also found that third- and fourth-generation Japanese Americans had similar or even higher levels of atherosclerosis, or hardening of the arteries – a major risk factor for heart disease, compared to white Americans.
The very low rate of heart disease in Japan among developed countries has been puzzling. Death rates from coronary heart disease in Japan have been less than half of that in the U.S. This holds true even among Japanese men born after World War II who adopted a Western lifestyle since childhood, and despite the fact that among these same men, risk factors for coronary heart disease (serum levels of total cholesterol, blood pressure and rates of type 2 diabetes) are very similar among men in the U.S. Additionally, the rate of cigarette smoking, another major risk factor, has been infamously high in Japan.
"Our study suggests that very high levels of omega-3 fatty acids have strong properties that may help prevent the buildup of cholesterol in the arteries," said Akira Sekikawa, M.D., Ph.D., study lead author and assistant professor of epidemiology at the University of Pittsburgh Graduate School of Public Health. "Increasing fish intake to two times a week for healthy people is currently recommended in the U.S. Our study shows much higher intake of fish observed in the Japanese may have strong anti-atherogenic effect."
Fish consumption among the Japanese is one of the highest in the world. Japanese men consume an average of 100 grams, equivalent to about 3.75 ounces, of fish every day from early in life. Meanwhile, Americans typically eat fish less than two times a week.
"The Japanese eat a very high level of fish compared to other developed countries," said Dr. Sekikawa. "While we don't recommend Americans change their diets to eat fish at these quantities because of concerns about mercury levels in some fish, increasing intake of omega-3 fatty acids in the U.S. could have a very substantial impact on heart disease. Given the similar levels of atherosclerosis in Japanese Americans and white Americans, it also tells us that lower levels of heart disease among Japanese men are much more likely lifestyle related than a result of genetic differences," said Dr. Sekikawa.
Omega-3 fatty acids are a type of polyunsaturated fat found primarily in fish. The two most potent omega-3 fatty acids are known as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) and are usually found in oily fishes, such as mackerel, salmon and tuna.

Eating Fish May Prevent Memory Loss and Stroke
The study found that people who ate fish high in omega-3 fatty acids (called DHA and EPA) three times or more per week had a nearly 26 percent lower risk of having the silent brain lesions that can cause dementia and stroke compared to people who did not eat fish regularly. Eating just one serving of this type of fish per week led to a 13 percent lower risk. The study also found people who regularly ate these types of fish had fewer changes in the white matter in their brains.
“While eating fish seems to help protect against memory loss and stroke, these results were not found in people who regularly ate fried fish,” said Jyrki Virtanen, PhD, RD, with the University of Kuopio in Finland. “More research is needed as to why these types of fish may have protective effects, but the omega-3 fatty acids EPA and DHA would seem to have a major role.”
Types of fish that contain high levels of DHA and EPA nutrients include salmon, mackerel, herring, sardines, and anchovies.
“Previous findings have shown that fish and fish oil can help prevent stroke, but this is one of the only studies that looks at fish’s effect on silent brain infarcts in healthy, older people,” said Virtanen. Research shows that silent brain infarcts, which are only detected by brain scans, are found in about 20 percent of otherwise healthy elderly people.

Fish Better than Olive Oil, Nuts vs. Heart Disease

Researchers have found that a diet rich in fish, seafood, and grains – also called polyunsaturated fats – is better at preventing heart disease than a diet containing olive oil, nuts, and avocados – called monounsaturated fats. Although both types of fats are healthy, people should probably include more of the first than the second in their diet to keep a healthy heart, the scientists say.

Too much cholesterol has long been linked to increasing risks of developing heart disease, but it has been less clear how the various dietary fats – saturated, monounsaturated and polyunsaturated – make people susceptible to the disease.__

These results suggest that polyunsaturated fat is a more suitable replacement than monounsaturated fat for dietary saturated fat, the scientists concluded.

Eating fish, omega-3 oils, lowers risk of memory problems
A diet rich in fish and omega-3 oils, may lower your risk of dementia and Alzheimer’s diseas, according to a study published in the November 13, 2007, issue of Neurology®, the medical journal of the American Academy of Neurology.
For the study, researchers examined the diets of 8,085 men and women over the age of 65 who did not have dementia at the beginning of the study. Over four years of follow-up, 183 of the participants developed Alzheimer’s disease and 98 developed another type of dementia.
The study found people who regularly consumed omega-3 rich oils, such as canola oil, flaxseed oil and walnut oil, reduced their risk of dementia by 60 percent compared to people who did not regularly consume such oils.
The study also found people who ate fish at least once a week had a 35-percent lower risk of Alzheimer’s disease and 40-percent lower risk of dementia.
Oily fish can protect against rheumatoid arthritis
Paris, France, Friday 13 June 2008: New data presented today at EULAR 2008, the Annual Congress of the European League Against Rheumatism in Paris, France, show that intake of oily fish is associated with a reduced risk of developing rheumatoid arthritis (RA).
For the first time, the intake of oily fish has been demonstrated to have a protective effect against the development of RA, reducing an individual's risk by 20-30%. Studying 1,899 subjects investigators concluded that the odds ratio (OR) for developing RA was 0.8 (0.7-1.0) for those who consumed oily fish 1-7 times per week or 1-3 times per month, compared with those who never, or seldom consumed oily fish. Interestingly, no significant association with RA risk was observed for consumption of fish oil supplements.

Eating fish and foods with omega-3 fatty acids linked to lower risk of age-related eye disease
Eating fish and other foods high in omega-3 fatty acids is associated with reduced risk of the eye disease age-related macular degeneration (AMD), according to a meta-analysis of nine previously published studies in the June issue of Archives of Ophthalmology, one of the JAMA/Archives journals.
Elaine W-T. Chong, M.B.B.S., of the University of Melbourne, Australia, and colleagues conducted a systematic review of studies published before May 2007 evaluating the fish consumption and overall omega-3 fatty acid intake for the prevention of AMD. A total of nine studies were identified with 88,974 participants, including 3,203 individuals with AMD.
When results from all nine studies were combined, a high dietary intake of omega-3 fatty acids was associated with a 38 percent reduction in the risk of late (more advanced) AMD, while eating fish twice a week was associated with a reduced risk of both early and late AMD.
Eat fish -- especially if you drink high levels of alcohol
Essential fatty acids (EFAs) are a necessary part of an individual's healthy diet.
New findings indicate that binge-drinking men have lower intakes of n-3 fats, one type of EFA.
This low intake exacerbates the already very low EFA levels.
Essential fatty acids (EFAs) are just that; an "essential" part of the total fat intake necessary for a healthy human diet. Most EFAs come from plants, but some are animal-sourced. A new study has found that men who binge drink have substandard intake of n-3 fats, one of two types of EFAs, indicating poor dietary choices with negative long-term health consequences.
"Essential fatty acids are important building blocks of living cells, making up a substantial part of cell walls," explained Norman Salem, Jr., chief of the Laboratory of Membrane Biochemistry & Biophysics at the National Institute on Alcohol Abuse and Alcoholism "EFAs also have many biological functions, and a lack of them leads to loss of growth and development, infertility, and a host of physiological and biochemical abnormalities." Salem is also the study's corresponding author.
The most important EFAs are polyunsaturated fatty acids (PUFA), said J. Thomas Brenna, professor of human nutrition and of chemistry & chemical biology at Cornell University. Particularly two types, Brenna noted: the omega-6 PUFA linoleic acid (LA), also called n-6 fats, and the omega-3 PUFA linolenic acid (ALA), also called n-3 fats. "Most Americans consume adequate amounts of LA in their diets through the use of vegetable oils, but tend to have low intakes of ALA," said Brenna.
"In summary," said Salem, "for those who drink, especially binge drinkers or those who drink more than one drink per day on average: make sure that you obtain your sources of n-3 fatty acids in the diet, that is, eat more fish."

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Jon's Health Tips: Red Wine

I drink a glass of red wine almost every day, even though I don’t particularly like it. I wish I could drink more, but I just can’t. I make up some of the deficiency by eating a lot of organic raisins (dried grapes.) In dried fruit eating organic is especially important because the contamination is concentrated.
I drink cabernet sauvignon from Chile, which has the highest concentration of resveratrol. Here’s why:

New 'Wine Diet' Adds Years to Your Life

If you're contemplating giving up wine for your diet...Don't! There are far too many studies now showing the significant long-term health benefits from a daily glass or two of red wine to worry about the extra calories.
Top U.S. killers are heart disease and cancer, but it doesn't have to be that way. One study shows men can lower their risk of heart disease by 50% by drinking two glasses of red wine per day. And women who drink one glass per day reduce their risk by 30%.
What makes red wine so healthy? Red grape skins, seeds and stems all contain high concentrations of compounds called polyphenols - more commonly known as antioxidants. These same antioxidants also help prevent certain types of cancer such as prostate, colon, and skin cancer.
Do you think high blood pressure is at epidemic levels? Perhaps it's because not enough Americans have wine savvy. Wine lovers now realize a glass of wine also helps your body excrete excess sodium, which lowers your blood pressure.
And now you can stop worrying about growing old. Red wine also has resveratrol, which was most recently linked by two studies in mice, to living longer and to showing signs of reducing the leading factors that cause Alzheimer's disease. It might be too soon to predict if the results in mice will be duplicated in humans, but it's a promising step.

Substance in red wine found to keep hearts young
How do the French get away with a clean bill of heart health despite a diet loaded with saturated fats? Scientists have long suspected that the answer to the so-called "French paradox" lies in red wine. Now, the results of a new study bring them closer to understanding why.
Researchers report that low doses of resveratrol -- a natural constituent of grapes, pomegranates, red wine and other foods -- can potentially boost the quality of life by improving heart health in old age.
Previous research has shown that high doses of resveratrol extend life in invertebrates and prevent early death in mice given a high-fat diet. The new study extends those findings, showing that resveratrol in low doses, beginning in middle age, can elicit many of the same benefits as a reduced-calorie diet.
"Resveratrol is active in much lower doses than previously thought," said Tomas Prolla, a UW professor of genetics and a senior author of the new report.
In short, the authors note that a glass of wine or food or supplements containing even small doses of resveratrol are likely to help stave off cardiac aging.
That finding, may also explain the remarkable heart health of people who live in some regions of France where diets are soaked in saturated fats but the incidence of heart disease, a major cause of mortality in the United States, is low. In France, meals are traditionally complemented with a glass of red wine.
Red Wine Compound Shown To Prevent Prostate and Breast Cancer
Researchers at the University of Alabama at Birmingham (UAB) have found that nutrients in red wine may help reduce the risk of developing prostate cancer.
The study involved male mice that were fed a plant compound found in red wine called resveratrol, which has shown anti-oxidant and anti-cancer properties. Other sources of resveratrol in the diet include grapes, raspberries, peanuts and blueberries.
An earlier UAB study published May 2006 in the same journal found resveratrol-fed female mice had considerable reduction in their risk of breast cancer.
Lamartiniere said his research team has been pleasantly surprised at the chemoprevention power of wine and berry polyphenols like resveratrol in animal models.
"A cancer prevention researcher lives for these days when they can make that kind of finding," Lamartiniere said. "I drink a glass a day every evening because I’m concerned about prostate cancer. It runs in my family."
Resveratrol in red wine could cut colorectal cancer risk
Drinking more than three glasses of red wine a week could cut the risk of colorectal cancer by almost 70 per cent, researchers told the 71st Annual Scientific Meeting of the American College of Gastroenterology in Las Vegas.
The potential benefits of the wine have been put down to the resveratrol content of the wine, and adds to an ever growing body of science linking the compound to a range of beneficial health effects, including brain and mental health, and cardiovascular health.
The new research, by Joseph Anderson, and his colleagues from the Stony Brook University in New York looked at the drinking habits of 360 red and white drinkers with similar lifestyles and found that, while white wine consumption was not found to have any association with colorectal cancer incidence, regular red wine consumption was linked to a 68 per cent reduced risk of the cancer.
And the researchers told attendees that the active component in wine that may be behind the apparent benefits is most likely resveratrol, an anti-fungal chemical that occurs naturally under the skin of red wine grapes.
“The concentration is significantly higher in red wine than in white wine, because the skins are removed earlier during white-wine production, lessening the amount that is extracted,” said Dr. Anderson.
Indeed, while resveratrol has been the subject of various studies, particularly in relation to heart health, recent studies have reported brain protecting effects from grape juice or wine – an effect linked to a synergy between the various polyphenols present.
A recent study using Concord grape juice by researchers from Tuft's University reported that the combination of the polyphenols could decrease the effects of aging on the brain.
The amount of resveratrol in a bottle of red wine can vary between types of grapes and growing seasons, and can vary between 0.2 and 5.8 milligrams per litre. But nearly all dark red wines – merlot, cabernet, zinfandel, shiraz and pinot noir – contain resveratrol.
However, experts are quick to warn that moderation is the key. A study from Harvard University last year reported that people who have three or more alcoholic drinks per day have a significantly higher risk of stroke. Lowest risk was observed for those who had one, or maybe two, drinks every other day.
Mounting evidence shows red wine antioxidant kills cancer
Researchers pinpoint how resveratrol induces pancreatic cancer cell death
Rochester researchers showed for the first time that a natural antioxidant found in grape skins and red wine can help destroy pancreatic cancer cells by reaching to the cell's core energy source, or mitochondria, and crippling its function. The study is published in the March edition of the journal, Advances in Experimental Medicine and Biology.
Yet despite widespread interest in antioxidants, some physicians are concerned antioxidants might end up protecting tumors. Okunieff's study showed there is little evidence to support that fear. In fact, the research suggests resveratrol not only reaches its intended target, injuring the nexus of malignant cells, but at the same time protects normal tissue from the harmful effects of radiation.
"Antioxidant research is very active and very seductive right now," Okunieff said. "The challenge lies in finding the right concentration and how it works inside the cell. In this case, we've discovered an important part of that equation. Resveratrol seems to have a therapeutic gain by making tumor cells more sensitive to radiation and making normal tissue less sensitive."
Resveratrol Could Protect Against Stroke
Resveratrol, a compound found in grapes, red wine and peanuts, can improve blood flow in the brain by 30 per cent, thereby reducing the risk of stroke, according to the results of a rat study.
Researchers at the National Taiwan Normal University and the National Chia-Yi University report that rats with induced reduction of blood flow (ischemia) in the brain experienced an improved blood flow from a single dose of resveratrol.
“We found that resveratrol administration… led to cerebral blood flow elevation and protected animals from ischemia-induced neuron loss,” said lead author Kwok Tung Lu.
Strokes occur when blood clots or an artery bursts in the brain and interrupts the blood supply to a part of the brain. It is the leading cause of disability and the third leading cause of death in Europe and the US. According to the Stroke Alliance for Europe (SAFE), about 575,000 deaths are stroke related in Europe every year. In the US, every 45 seconds someone will experience a stroke, according to the American Stroke Association.

Red Wine Compound May Extend Life
- Resveratrol, a polyphenol found in red wine, extended survival rates of mice and prevented the negative effects of high-calorie diets, says a new study published in Nature.
The study, described by an independent expert as potentially “the breakthrough of the year”, adds to a growing body of research linking resveratrol and red wine consumption to a range of beneficial health effects, including brain and mental health, and cardiovascular health.
"The "healthspan" benefits we saw in the obese mice [fed] resveratrol, such as increased insulin sensitivity, decreased glucose levels, healthier heart and liver tissues, are positive clinical indicators and may mean we can stave off in humans age-related diseases such as type 2 diabetes, heart disease, and cancer, but only time and more research will tell," said co-author David Sinclair from Harvard Medical School.

Red wine again linked to slowing Alzheimer's
A Mount Sinai School of Medicine study found giving mice with amyloid plaques red wine slows their memory loss and brain cell death - adding to a body of science linking compounds in the beverage to slowing the Alzheimer's disease-related symptom.
For several months, the Mount Sinai mice were given cabernet sauvignon or ethanol in their drinking water, while another group of mice drank plain water. All the mice had amyloid plaques in their brains that occur in humans with Alzheimer's disease.
The research team, led by Dr. Giulio Maria Pasinetti, assessed the mice's memory by testing their ability to get out of a maze. The wine-drinking mice were able to exit the maze significantly faster than those drinking alcohol-spiked water or water only, the scientists found.
The study only advocates moderate red wine consumption as part of an overall healthy lifestyle.

Wine may protect against dementia
There may be constituents in wine that protect against dementia. This is shown in research from the Sahlgrenska Academy at University of Gothenburg in Sweden.
“The group that had the lowest proportion of dementia were those who had reported that the only alcohol they drank was wine,” says Professor Lauren Lissner, who directs the study in collaboration with Professor Ingmar Skoog, both with the Sahgrenska Academy.
Daily Glass of Wine Could Improve Liver Health

Researchers at UC San Diego School of Medicine are challenging conventional thinking with a study showing that modest wine consumption, defined as one glass a day, may not only be safe for the liver, but may actually decrease the prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD).
The study, which appears in the June 2008 issue of the journal Hepatology, showed that for individuals who reported drinking up to one glass of wine per day, as compared to no alcohol consumption, the risk of liver disease due to NAFLD was cut in half. In contrast, compared with wine drinkers, individuals who reported modest consumption of beer or liquor had over four (4) times the odds of having suspected NAFLD.
NAFLD is the most common liver disease in the United States, affecting over 40 million adults. Previous research has shown that as many as five percent of adults with NAFLD will develop cirrhosis. The major risk factors for NAFLD are similar to many of the risk factors for cardiovascular disease—obesity, diabetes, high triglycerides, and high blood pressure. Multiple studies have shown that modest alcohol consumption may reduce the risk for heart disease. However, recommendations for modest alcohol consumption in individuals at risk for cardiovascular disease have overlooked that these same people are also at an increased risk for NAFLD. Thus, there exists a dilemma as to whether modest alcohol consumption for the heart is safe in regards to the liver. The UC San Diego investigators sought to clarify this important question.
“The results of this study present a paradigm shift, suggesting that modest wine consumption may not only be safe for the liver but may actually decrease the prevalence of NAFLD. The odds of having suspected NAFLD based upon abnormal liver blood tests was reduced by 50 percent in individuals who drank one glass of wine a day,” said Jeffrey Schwimmer, M.D., associate professor of gastroenterology, hepatology and nutrition, Department of Pediatrics, UC San Diego School of Medicine. The result remained constant, even after adjusting for age, sex, race, education, income, diet, physical activity, body mass index, and other markers of health status.
“Because this effect was only seen with wine, not in beer or liquor, further studies will be needed to determine whether the benefits seen were due to the alcohol or non-alcohol components of wine,” added Schwimmer.
Red wine's resveratrol may help battle obesity
Resveratrol, a compound present in grapes and red wine, reduces the number of fat cells and may one day be used to treat or prevent obesity, according to a new study.
The new finding is consistent with the theory that the resveratrol in red wine explains the French paradox, the observation that French people eat a relatively high-fat diet but have a low death rate from heart disease.
"Resveratrol has anti-obesity properties by exerting its effects directly on the fat cells," Fischer-Posovszky said. "Thus, resveratrol might help to prevent development of obesity or might be suited to treating obesity."
Fischer-Posovszky cautioned that, while the health benefits of resveratrol seem promising, there is not sufficient knowledge about the effects of long-term treatment. One small study found that a single dose of up to 5 grams of resveratrol (much higher than the amount in a bottle of red wine) caused no serious ill effects in healthy volunteers, she pointed out.
Potential new role for red grape seeds in treatment of Alzheimer's disease
Mount Sinai researchers have discovered that polyphenolics derived from red grape seeds may be useful agents to prevent or treat Alzheimer's disease (AD).
Over the past few years researchers at Mount Sinai's Center of Excellence set out to determine whether the FDA's recommended daily servings of red wine (approximately one glass for women and two glasses for men), might have the same positive health effect that studies and surveys of populations had shown in the past. They are currently investigating nearly 5000 compounds contained in red wine.
"Grape seed extracts significantly reduced Alzheimer's disease - type cognitive deterioration. Red grapes might even help prevent memory loss in people that did not yet developed Alzheimer's disease. "
Red Wine Fights Breast Cancer
Early laboratory research has shown that resveratrol, a common dietary supplement, suppresses the abnormal cell formation that leads to most types of breast cancer, suggesting a potential role for the agent in breast cancer prevention. Resveratrol is a natural substance found in red wine and red grapes. It is sold in extract form as a dietary supplement at most major drug stores.
"Resveratrol has the ability to prevent the first step that occurs when estrogen starts the process that leads to cancer by blocking the formation of the estrogen DNA adducts. We believe that this could stop the whole progression that leads to breast cancer down the road," said Eleanor G. Rogan, Ph.D., a professor in the Eppley Institute for Research in Cancer and Allied Diseases at the University of Nebraska Medical Center.

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Jon's Health Tips: Aspirin

I take aspirin regularly. So does my internist. Here’s why:
Aspirin, long known to relieve fevers, aches and pain, has served an increasingly bigger role in health care in recent years. A daily aspirin may help lower the risk of heart attack and clot-related strokes. An estimated 20 million men and women take a low dose of aspirin (81-325 mg daily) to control heart disease.
The November issue of Mayo Clinic Women’s HealthSource discusses why millions of Americans opt to take a daily low-dose aspirin and how this therapy seems to work a bit differently for women and men.
Aspirin reduces the clumping action of platelets, the blood’s clotting cells. Clotting helps a cut or wound stop bleeding. But clots also form within blood vessels that supply the heart and brain. If the vessels are already narrowed from a buildup of fatty deposits, a blood clot can quickly block an artery, causing a heart attack or stroke.
Early studies on aspirin therapy only involved men. New studies confirm that women may benefit from aspirin therapy, too, but not exactly the way men benefit. Recent studies identified these differences and similarities between the sexes and showed that aspirin:
n Helps prevent a first stroke for women. There’s no risk reduction for men.
n Helps prevent a first heart attack for women over age 65 and for all men.
n Helps prevent a second heart attack for men and women, regardless of age.
Women who take low to moderate doses of aspirin have a reduced risk of death from any cause, and especially heart disease–related deaths, according to a report in the March 26 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. Women who reported using aspirin currently had a 25 percent lower risk of death from any cause than women who never used aspirin regularly. The association was stronger for death from cardiovascular disease (women who used aspirin had a 38 percent lower risk) than for death from cancer (women who used aspirin had a 12 percent lower risk).
People with prehypertension who are treated with aspirin may experience significant reductions in blood pressure—but only if they take the pill before bedtime, and not when they wake up in the morning.
People with prehypertension (a blood pressure reading between normal and high; when systolic blood pressure is between 120 and 139 or diastolic blood pressure is between 80 and 89 on multiple readings) are at significant risk of hypertension, or consistently high blood pressure—the biggest risk factor for heart disease and stroke, the two leading causes of death in the Western world.
Different types of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, naproxen, and aspirin, appear to be equally effective in lowering the risk of Alzheimer’s disease, according to the largest study of its kind published in the May 28, 2008, online issue of Neurology®, the medical journal of the American Academy of Neurology. Experts have debated whether a certain group of NSAIDs that includes ibuprofen may be more beneficial than another group that includes naproxen and aspirin.
Using information from six different studies, researchers examined data on NSAID use in 13,499 people without dementia. Over the course of these six studies, 820 participants developed Alzheimer’s disease.
Researchers found that people who used NSAIDs had 23 percent lower risk of developing Alzheimer’s disease compared to those who never used NSAIDs. The risk reduction did not appear to depend upon the type of NSAID taken.
Common painkillers like aspirin and ibuprofen appear to lower a man's PSA level, the blood biomarker widely used by physicians to help gauge whether a man is at risk of prostate cancer.
But the authors of the study, which appears online Sept. 8 in the journal Cancer, caution that men shouldn't take the painkillers in an effort to prevent prostate cancer just yet.
"We showed that men who regularly took certain medications like aspirin and other non-steroidal anti-inflammatory drugs, or NSAIDS, had a lower serum PSA level," said first author Eric A. Singer, M.D., M.A., a urology resident at the University of Rochester Medical Center. "But there's not enough data to say that men who took the medications were less likely to get prostate cancer.
American Heart Association Scientific Statement: Many doctors should change the way they prescribe pain relievers for chronic pain in patients with or at risk for heart disease based on accumulated evidence that nonsteroidal anti-inflammatory drugs (NSAIDs), with the exception of aspirin, increase risk for heart attack and stroke, according to an American Heart Association statement published today in Circulation: Journal of the American Heart Association.
People should talk with their doctor before starting an aspirin a day. Regular aspirin use increases the risk of stomach ulcers or a bleeding (hemorrhagic) stroke. Current medical literature suggests that women who are at high risk of heart disease should be on daily aspirin therapy. However, people should weigh the benefits and risks with their doctor.

Aspirin can reduce colorectal cancer risk
Safer drugs needed before regular preventive therapy can be recommended
A study of Medicare patients with osteoarthritis provides additional evidence that non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin reduce the risk of colorectal cancer.

Researchers found that men who used aspirin regularly experienced a significantly lower risk of colorectal cancer, including distal colon cancer, proximal colon cancer and rectal cancer, even after controlling for other risk factors. The reduction in risk was seen in both early (stage I/II) and advanced (stage III/IV) colorectal cancers.

"The compelling evidence that chronic use of aspirin or certain NSAIDS can substantially lower the risk of colon cancer has important implications, especially because colon cancer is the second leading cause of cancer death," writes Dr. Markowitz, the Francis Wragg Ingalls Professor of Cancer Genetics at UHCMC and Case Western Reserve University School of Medicine.

Harvard researchers' findings demonstrated that two-thirds of colon cancers have high levels of expression of the COX-2 enzyme, which is blocked by aspirin. Individuals who regularly used aspirin over a course of several years demonstrated a 36% decrease in the risk of developing one of these high COX-2 expressing colon cancers. These results again demonstrated that drugs that block COX-2 can decrease the risk of colon cancer, and demonstrated that such drugs specifically target those individuals whose tumor development is encouraged by the action of the COX-2 enzyme.

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Jon's Health Notes: Green Tea

One of my hobbies is collecting information on research involving personal health matters. I’d like to share some of this with you.

I try to drink at least 2 strong cups of green tea a day, preferably with a little bit of orange juice. Here’s why:

Reader quote: “ Note, though, that green tea is contraindicated with Coumadin, or so my husband's cardiologist says.”

Drinking Tea May Offer Health Benefits

Tea drinkers who opt for black, oolong, green or white teas may find that these beverages offer health benefits. The April issue of Mayo Clinic Health Letter covers what is -- and isn’t -- known about the health effects of drinking tea.
Black, oolong, green or white teas have a common origin. Each is produced from the leaves of the Camellia sinensis bush. The leaves are loaded with flavonoids and other polyphenols that work as antioxidants, possibly lowering the risk of some diseases.
While numerous studies have found possible benefits, the actual benefits of drinking tea are not certain. Most research about tea’s benefits is based on population (epidemiological) studies. Findings are limited because factors other than tea consumption could influence the results. Here’s some of what’s known about tea’s potential benefits:
Cardiovascular: It’s still uncertain if drinking tea over long periods might positively affect cholesterol levels, blood pressure and atherosclerosis. There’s some early evidence that regularly drinking green tea may reduce heart attack risk or atherosclerosis. .
Bone and joint health: Early laboratory research indicates green tea could be beneficial in reducing inflammation related to arthritis and slowing cartilage breakdown. Some early data indicate that regular tea consumption might improve bone mineral density in older women.
Memory: Studies are limited, but a recent one found that older adults in Japan who drank green tea daily showed less risk of memory difficulty, compared with those who didn’t drink tea regularly.
While there’s still much to learn about tea’s health benefits, the potential benefits seem to be in the cup, not in supplements or tea extract capsules. So far, there’s no certainty that the compounds in supplements are the same ones in tea, and even less certainty that these supplements might provide the same potential health benefits as tea.
Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
Concentrated chemicals derived from green tea dramatically boosted production of a group of key detoxification enzymes in people with low levels of these beneficial proteins, according to researchers at Arizona Cancer Center.
These findings suggest that a green tea concentrate might help some people strengthen their metabolic defense against toxins capable of causing cancer.
“This is the first clinical study to show proof that chemicals in green tea can increase detoxification enzymes in humans,” Chow said. “There may be other mechanism in play by which green tea may protect against cancer development, but this is a good place to start.”
Green Tea May Help Fight Rheumatoid Arthritis

A new study from the University of Michigan Health System suggests that a compound in green tea may provide therapeutic benefits to people with rheumatoid arthritis.

Researchers found that the compound inhibited the production of several molecules in the immune system that contribute to inflammation and joint damage in people with rheumatoid arthritis.

The compound from green tea also was found to suppress the inflammatory products in the connective tissue of people with rheumatoid arthritis._

Green tea may help prevent autoimmune diseases

Green tea may help protect against autoimmune disease, Medical College of Georgia researchers say.__

Approximately 30 percent of elderly Americans suffer from degrees of dry mouth, says Dr. Stephen Hsu, a researcher in the MCG School of Dentistry and lead investigator on the study. Only 5 percent of the elderly in China, where green tea is widely consumed, suffer from the problem.

Researchers already know that one component of green tea – EGCG – helps suppress inflammation, according to Dr. Hsu.__

“So, we suspected that green tea would suppress the inflammatory response of this disease. Those treated with the green tea extract beginning at three weeks, showed significantly less damage to those glands over time.”_

Researchers also suspect that the EGCG in green tea can turn on the body’s defense system against TNF-alpha – a group of proteins and molecules involved in systemic inflammation. TNF-alpha, which is produced by white blood cells, can reach out to target and kill cells. Further study could help determine green tea’s protective role in other autoimmune diseases, including lupus, psoriasis, scleroderma and rheumatoid arthritis, he says.

Green tea may protect from inflamed bladder

Herbal agents could be used to treat inflammatory bladder diseases, according to a preliminary study that looked at the ability of green tea to protect bladder cells from inflammation. The University of Pittsburgh School of Medicine study found that components of green tea protected bladder cells from damage in culture.

Green tea, reported to have many health benefits, is rich in powerful antioxidants that make it a possible remedy for many medical conditions. It is comprised of catechins – plant metabolites that provide it with many anti-oxidative properties.

Green tea may protect brain cells against Parkinson's disease
Does the consumption of green tea, widely touted to have beneficial effects on health, also protect brain cells" Authors of a new study being published in the December 15th issue of Biological Psychiatry share new data that indicates this may be the case. The authors investigated the effects of green tea polyphenols, a group of naturally occurring chemical substances found in plants that have antioxidant properties, in an animal model of Parkinson’s disease.
The authors discovered that green tea polyphenols protect dopamine neurons that increases with the amount consumed. They also show that this protective effect is mediated by inhibition of the ROS-NO pathway, a pathway that may contribute to cell death in Parkinson’s.
Milk eliminates cardiovascular health benefits of tea

Research published in the European Heart Journal has found that the protective effect that tea has on the cardiovascular system is totally wiped out by adding milk.

Tests on volunteers showed that black tea significantly improves the ability of the arteries to relax and expand, but adding milk completely blunts the effect. But, again, adding milk blocked the effect.
Citrus Juice, Vitamin C Give Staying Power to Green Tea Antioxidants
To get more out of your next cup of tea, just add juice.
A study found that citrus juices enable more of green tea's unique antioxidants to remain after simulated digestion, making the pairing even healthier than previously thought.
The study compared the effect of various beverage additives on catechins, naturally occurring antioxidants found in tea. Results suggest that complementing green tea with either citrus juices or vitamin C likely increases the amount of catechins available for the body to absorb.
Catechins (pronounced KA'-teh-kins), display health-promoting qualities and may be responsible for some of green tea's reported health benefits, like reduced risk of cancer, heart attack and stroke. The problem, Ferruzzi said, is that catechins are relatively unstable in non-acidic environments, such as the intestines, and less than 20 percent of the total remains after digestion.
"Off the bat you are eliminating a large majority of the catechins from plain green tea," Ferruzzi said. "We have to address this fact if we want to improve bodily absorption."
Ferruzzi tested juices, creamers and other additives that are either commonly added to fresh-brewed tea or used to make ready-to-drink tea products by putting them through a model simulating gastric and small-intestinal digestion. Citrus juice increased recovered catechin levels by more than five times, the study found. Ascorbic acid, or vitamin C, used to increase shelf life in ready-to-drink products, increased recovered levels of the two most abundant catechins by sixfold and 13-fold, respectively.
Lemons and tea go even better together than their popularity might suggest. Lemon juice caused 80 percent of tea's catechins to remain, the study found. Following lemon, in terms of stabilizing power, were orange, lime and grapefruit juices. Ferruzzi said both vitamin C and citrus juices must interact with catechins to prevent their degradation in the intestines, although data made it clear that citrus juices have stabilizing effects beyond what would be predicted solely based on their vitamin C content.

"If you want more out of your green tea, add some citrus juice to your cup after brewing or pick a ready-to-drink product formulated with ascorbic acid," Ferruzzi said.

Ready-to-drink green tea products should optimally contain 100-200 mg of catechins, but oftentimes do not have sufficient levels of tea extract since some people do not like green tea's flavor, Ferruzzi said.

Although this study only examined green tea, Ferruzzi said he suspects that some of the results also could apply to black tea, which is produced by fermenting green tea. Many prefer black tea's flavor, although it contains lower total levels of catechins.

Green tea helps beat superbugs
Green tea can help beat superbugs according to Egyptian scientists speaking today (Monday 31 March 2008) at the Society for General Microbiology’s 162nd meeting being held this week at the Edinburgh International Conference Centre.
The pharmacy researchers have shown that drinking green tea helps the action of important antibiotics in their fight against resistant superbugs, making them up to three times more effective.
Green tea is a very common beverage in Egypt, and it is quite likely that patients will drink green tea while taking antibiotics. The medical researchers wanted to find out if green tea would interfere with the action of the antibiotics, have no effect, or increase the medicines’ effects.
“We tested green tea in combination with antibiotics against 28 disease causing micro-organisms belonging to two different classes,” says Dr Mervat Kassem from the Faculty of Pharmacy at Alexandria University in Egypt. “In every single case green tea enhanced the bacteria-killing activity of the antibiotics. For example the killing effect of chloramphenicol was 99.99% better when taken with green tea than when taken on its own in some circumstances.”
Green tea also made 20% of drug-resistant bacteria susceptible to one of the cephalosporin antibiotics. These are important antibiotics that new drug resistant strains of bacteria have evolved to resist.
The results surprised the researchers, showing that in almost every case and for all types of antibiotics tested, drinking green tea at the same time as taking the medicines seemed to reduce the bacteria’s drug resistance, even in superbug strains, and increase the action of the antibiotics. In some cases, even a low concentration of green tea was effective.


Green Tea Shown to Possess Antitumor Effect in Breast Cancer
A team of scientists have shown that green tea has antitumor effect in breast cancer cells.
Cancer is a disease caused by the increased proliferation of cells which group and form a lump called tumor. Tumors can be benign or malignant. Cells from malignant tumors break away from the original tumor and spread to other parts of the body growing and forming new tumors. They can invade, penetrate into blood and lymphatic vessels, circulate via the bloodstream and can grow in a normal organ or tissue anywhere in the body. Unfortunately treatment options for metastasis are very limited and usually represent the end stage of the disease.
Unlike malignant tumors, benign tumors do not invade and, with very rare exceptions, are not life threatening. Chemoprevention broadly implies the use of a chemical substance of either natural or synthetic origin, to prevent, hamper, arrest or reverse a disease. Phytochemicals are plant based non nutritive components with substantial medicinal properties.
Dr. Maheshwari’s study observed that green tea can inhibit the invading capacity of these breast cancer cells and have also identified the mechanisms involved in death inducing and invasion inhibiting effects of green tea. Epidemiological studies also suggest that the risk of breast cancer is found to be less in Asian countries consuming green tea. These studies have greater clinical significance since the ability of these phytochemicals to activate anti-cancer program of tumor cells might determine the success of chemotherapy.
Green tea is effective in delaying tumor incidence as well as in reducing the tumor burden. Green tea was found to inhibit growth of tumors as well as induce death of breast cancer cells.

Ingredient Found In Green Tea Significantly Inhibits Breast Cancer Growth In Female Mice
Green tea is high in the antioxidant EGCG (epigallocatechin-3- gallate) which helps prevent the body’s cells from becoming damaged and prematurely aged. Studies have suggested that the combination of green tea and EGCG may also be beneficial by providing protection against certain types of cancers, including breast cancer. A new study conducted by researchers at the University of Mississippi researchers now finds that consuming EGCG significantly inhibits breast tumor growth in female mice. These results bring us one step closer to better understanding the disease and potentially new and naturally occurring therapies.
Epidemiological studies suggest that green tea and its major constituent, EGCG, can provide some protection against cancer. Because these studies were very limited, the anti-cancer mechanism of green tea and EGCG was not clear. As a result, the researchers examined whether drinking EGCG (just the antioxidant infused in water) inhibited the following: expression of VEGF (vascular endothelial growth factor, which is found in a variety of breast cancer types); tumor angiogenesis (thought to help tumors expand by supplying them with nutrients); and the growth of breast cancer in female mice.
Dr. Gu, the senior researcher for the study, hypothesized that the reason for the link between EGCG and the reductions in the cancer data was because EGCG directly targets both tumor blood vessels and tumor cells of breast cancer for suppressing the new blood vessels formation in breast tumor, the proliferation and migration of breast cancer cells.
Gu concluded by saying, “In this study we have demonstrated that the frequent ingestion of EGCG significantly inhibits breast tumor growth, VEGF expression and tumor angiogenesis in mice. We believe our findings will help lead to new therapies for the prevention and treatment of breast cancer in women.”

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