Possible Cure for Leukemia Found in Fish Oil

ΩA compound produced from fish oil that appears to target leukemia stem cells could lead to a cure for the disease, according to Penn State researchers.The compound -- delta-12-protaglandin J3, or D12-PGJ3 -- targeted and killed the stem cells of chronic myelogenous leukemia, or CML, in mice, said Sandeep Prabhu, associate professor of immunology and molecular toxicology in the Department of Veterinary and Medical Sciences. The compound is produced from EPA -- Eicosapentaenoic Acid -- an Omega-3 fatty acid found in fish and in fish oil, he said."Research in the past on fatty acids has shown the health benefits of fatty acids on cardiovascular system and brain development, particularly in infants, but we have shown that some metabolites of Omega-3 have the ability to selectively kill the leukemia-causing...

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Starch Intake May Influence Risk for Breast Cancer Recurrence

ΩResearchers have linked increased starch intake to a greater risk for breast cancer recurrence."The results show that it's not just overall carbohydrates, but particularly starch," said Jennifer A. Emond, M.S., a public health doctoral student at the University of California, San Diego. "Women who increased their starch intake over one year were at a much likelier risk for recurring."Researchers conducted a subset analysis of 2,651 women who participated in the Women's Healthy Eating and Living (WHEL) Dietary Intervention Trial, a plant-based intervention trial that enrolled about 3,088 survivors of breast cancer. WHEL researchers studied breast cancer recurrence and followed the participants for an average of seven years.The subset analysis involved an examination of how changes in carbohydrate...

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Virgin Olive Oil & Fish Fatty Acids Help Prevent Acute Pancreatitis

ΩScientists at the University of Granada have shown that oleic acid and hydroxytyrosol –present in a particularly high concentration in virgin olive oil– and n-3 polyunsaturated fatty acids –found in fish– relieve the symptoms of pancreatitis.The researchers evaluated the role of Mediterranean diet ingredients in the prevention and mitigation of cell damage.Oleic acid and hydroxytyrosol –present in a particularly high concentration in virgin olive oil– and n-3 polyunsaturated fatty acids –found in fish– affect the cellular mechanisms involved in the development of acute pancreatitis, a disease of oxidative-inflammatory etiology. Therefore, oleic acid and hydroxytyrosol can be considered potential functional ingredients, as they may prevent or mitigate this disease.Such was the conclusion drawn...

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Can vitamin B12 reduce stroke risk?

A commentary by Dr. David Spence of The University of Western Ontario and Dr. Meir Stampfer of the Harvard School of Public Health in today's Journal of the American Medical Association (JAMA) argues that vitamin therapy still has a role to play in reducing stroke.Vitamin B therapy was once widely used to lower homocysteine levels. Too much of this amino acid in the bloodstream was linked to increased risk of stroke and heart attack. But several randomized trials found lowering homocysteine levels with B vitamins did not result in a cardiovascular benefit. And a study by Dr. Spence, a scientist with the Robarts Research Institute at Western's Schulich School of Medicine & Dentistry, found Vitamin B therapy actually increased cardiovascular risk in patients with diabetic nephropathy.Dr....

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Is it who drinks wine that makes the difference?

ΩWine consumers, especially in comparison with spirits drinkers, have been shown to have higher levels of education and income, to consume a healthier diet, be more physically active, and have other characteristics that are associated with better health outcomes. However, epidemiologic studies have been inconsistent in showing that, after adjustment for all associated lifestyle factors, consumers of wine have lower risk of cardiovascular disease and mortality than do consumers of other beverages.A study based on the long-term follow up of a group of older Americans concluded that the associated lifestyle habits and environmental factors of wine consumers largely explained their better health outcomes. Forum reviewers were concerned about some of the methodological approaches used, and believed...

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Mediterranean diet gives longer life

Ω A Mediterranean diet with large amounts of vegetables and fish gives a longer life. This is the unanimous result of four studies to be published by the Sahlgrenska Academy at the University of Gothenburg. Research studies ever since the 1950s have shown that a Mediterranean diet, based on a high consumption of fish and vegetables and a low consumption of animal-based products such as meat and milk, leads to better health.Study on older peopleScientists at the Sahlgrenska Academy have now studied the effects of a Mediterranean diet on older people in Sweden. They have used a unique study known as the "H70 study" to compare 70-year-olds who eat a Mediterranean diet with others who have eaten more meat and animal products. The H70 study has studied thousands of 70-year-olds in the Gothenburg...

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Lean Beef is Good for Heart Health?

A new study published in the January 2012 edition of American Journal of Clinical Nutrition shows that beef can play a role in a cholesterol-lowering diet, despite commonly held beliefs. The study found that diets including lean beef every day are as effective in lowering total and LDL "bad" cholesterol as the "gold standard" of heart-healthy diets (DASH, Dietary Approaches to Stop Hypertension). The Beef in an Optimal Lean Diet (BOLD) clinical study (Effects on Lipids, Lipoproteins and Apolipoproteins),1 conducted by The Pennsylvania State University (PSU) researchers, evaluated adults with moderately elevated cholesterol levels, measuring the impact of diets including varying amounts of lean beef on total and LDL cholesterol levels. Study participants experienced a 10 percent decrease in...

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Dairy Foods Research - 2011

ΩIn 2011 alone, there has been an abundance of published research from world renowned nutritional scientists and universities, revealing the health benefits of dairy. To name a few:• According to a U.S. study published in February's Current Nutrition and Food Science, milk provides necessary nutrients without adversely impacting body weight in children and adolescents.• In Australia, researchers found that consumption of low-fat dairy may help decrease the risk for elevated blood pressure and, regardless of fat content, fluid dairy foods are associated with a reduced risk of elevated blood pressure.• A French study found a lower incidence of metabolic syndrome, type 2 diabetes and abnormal levels of fasting blood glucose was associated with higher consumption of dairy products and calcium.•...

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Compound in Apples Inhibits E. coli

ΩA compound that is abundant in apples and strawberries inhibits the highly pathogenic E. coli O157:H7 biofilms while sparing a beneficial strain of E. coli that also forms biofilms in the human gut, according to a paper in the December 2011 issue of the journal Infection and Immunology.Transcriptome analysis revealed that the compound, called phloretin, suppresses toxin and other genes involved in O157:H7 pathology and biofilm formation. And in a rat model of colitis, phloretin, reduced colon inflammation and body weight loss. "Phloretin has a triple biological activity as an antioxidant compound, a biofilm inhibitor, and an anti-inflammatory agent," says corresponding author Jintae Lee of Yeungnam University, Gyeongsan, Korea.E. coli O157:H7 causes hemorrhages in the intestine. To date,...

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Weight Regain After Loss Potentially Dangerous

ΩThe holidays are upon us and, for many Americans that means some degree of weight gain and the subsequent New Year’s resolution to diet.However, shedding the pounds may have some negative consequences on the overall health of older women if the weight loss is not maintained, according to a new study by researchers at Wake Forest Baptist Medical Center.Published recently in the American Journal of Clinical Nutrition, the study showed that some older women who lose weight gain a lot of their weight back within a year. Importantly, the weight regained is mostly in the form of fat, rather than muscle.“The body composition of some of the women was worse than before their weight loss,” said Barbara Nicklas, Ph.D., a gerontologist at the J. Paul Sticht Center on Aging and Rehabilitation at Wake...

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Association of lifestyle and environmental factors with the risk of cancer

ΩIt has been well established that certain lifestyle habits relate to the risk of certain cancers (e.g., smoking and lung cancer). In a well-done analysis, the authors estimate the proportion of cancer in the population associated with a variety of lifestyle and environmental factors."Tobacco smoking is by far the most important risk factor for cancer in the UK, responsible for 60 000 cases (19.4% of all new cancer cases) in 2010. The relative importance of other exposures differs by sex. In men, deficient intake of fruits and vegetables (6.1%), occupational exposures (4.9%) and alcohol consumption (4.6%) are next in importance, while in women, it is overweight and obesity (because of the effect on breast cancer) – responsible for 6.9% of cancers, followed by infectious agents (3.7%)."Forum...

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Statins accelerate depletion of plaque in arteries

ΩIn a new study, NYU Langone Medical Center researchers have discovered how cholesterol-lowering drugs called statins promote the breakdown of plaque in the arteries. The study was published online by the journal PLoS One on December 6, 2011.The findings support a large clinical study that recently showed patients taking high-doses of the cholesterol-lowering medications not only reduced their cholesterol levels but also reduced the amount of plaque in their arteries. However, until now researchers did not fully understand how statins could reduce atherosclerosis, the accumulation of fat and cholesterol that hardens into plaque in arteries, a major cause of mortality in Western countries. High blood cholesterol is a major culprit in atherosclerosis. As a result of narrowing arteries, blood...

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Statins = reduced mortality in flu patients

ΩThe two main ways to prevent and control influenza today are annual immunization and antiviral drugs. A team of investigators has found that statins, cholesterol-lowering drugs, may offer an additional treatment to complement these approaches and reduce mortality among patients hospitalized with influenza. The findings are published in The Journal of Infectious Diseases and are now available online.In an observational study led by Meredith L. Vandermeer, MPH, then with the Oregon Public Health Division in Portland, researchers used data for hospitalized adults during the 2007-2008 influenza season to evaluate the association between patients prescribed statins and influenza-related deaths. The data were drawn from the Centers for Disease Control and Prevention's Emerging Infections Program,...

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Caffeine and physical performance

ΩComplete report"Caffeine is the most dynamic and broad-ranging ergogenic aid that I know of. That is, there are aids that could specifically help strength or specifically help long-term endurance, whereas caffeine affects activities that are as short as a minute or as long as several hours; these activities could be aerobic or anaerobic in nature and so on. From that point of view, caffeine is a more general compound that can be used to enhance performance or endurance than any other aid that I could name. There is no question that it is a very potent ergogenic ai...

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Plant-Based Food Supplements Contain High Levels of Cancer Causing Agents

ΩWhile many consumers equal 'natural' with 'safe', botanicals and botanical preparations such as plant-based food supplements may contain compounds, like the so called alkenylbenzenes, that are of concern for human health. At high doses these chemical compounds can cause liver cancer in experimental animals. A new study, published in the last issue of the journal Food and Nutrition Sciences, reveals that in many plant-based food supplements levels of these compounds are so low that they are of no concern. Although there are also plant-based food supplements on the market that contain alkenylbenzenes at levels comparable to those causing tumours in laboratory animals. This indicates a need for better regulation and quality control of plant-based food supplements containing alkenylbenzenes.Botanicals...

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Working moms feel better than stay-at-home moms, study finds

ΩMothers with jobs report fewer symptoms of depression, better overall healthMothers with jobs tend to be healthier and happier than moms who stay at home during their children's infancy and pre-school years, according to a new study published by the American Psychological Association.Researchers analyzed National Institute for Child Health and Human Development Study of Early Child Care and Youth Development data, beginning in 1991 with interviews of 1,364 mothers shortly after their child's birth and including subsequent interviews and observations spanning more than 10 years. The findings were published in the December issue of APA's Journal of Family Psychology."In all cases with significant differences in maternal well-being, such as conflict between work and family or parenting, the...

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Vitamin D deficiency

ΩVitamin D deficiency is higher among certain demographic segments, including women, the elderly, and the obese. All three groups also share an increased risk of pelvic floor problems, including urinary incontinence. Could there be a connection? Perhaps so, according to recent research. A study published in Obstetrics & Gynecology compared vitamin D levels with incidence of various forms of pelvic floor disorder among 1,881 women, average age 48. Those with low levels of vitamin D (characterized as less than 30 nanograms per milliliter, or ng/ml) had a 170% increased risk of urinary incontinence, compared to those with higher blood levels. Why might this be? As a hormone, vitamin D supports a myriad of bodily functions, including maintenance of muscle and bone. As a result, deficiency...

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Fruits/ Vegetables Reduce/Increase Risk of Some Cancers

ΩThe effects of fruit and vegetable consumption on colorectal cancer (CRC) appear to differ by site of origin, according to a new study published in the October issue of the Journal of the American Dietetic Association. Researchers found that within the proximal and distal colon, brassica vegetables (Brussels sprouts, cabbage, cauliflower and broccoli) were associated with decreased risk of these cancers. A lower risk of distal colon cancer was associated with eating more apples, however an increased risk for rectal cancer was found with increasing consumption of fruit juice."Fruits and vegetables have been examined extensively in nutritional research in relation to CRC, however, their protective effect has been subject to debate, possibly because of different effects on different subsites...

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Jon's Health Tips - Latest Health Research

1. This is kind of weird and a little disturbing: my weekday soccer games are in the evening:Waking later and being active later put people at greater risk of dementia2. I like to think of my workplace as flexible:A flexible workplace initiative improved employees' health behavior and well-being, including a rise in the amount and quality of sleep and better health management3. This is really good news to me:Physical Fitness Trumps Body Weight in Reducing Death Risks4. I don't eat a whole lot of eggs, dairy, meat or soy. I'm still not worried about the quality of my protein:Eggs, dairy and meat proteins have a score of 1.0. Soy protein is the only widely available high-quality plant-based protein that achieves this score.5. I do eat a lot of fish (and take omega -3 supplements), fruits, vegetables,...

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Morning Exercise Better

ΩWaking later and being active later put people at greater risk of dementiaOlder women with weaker circadian rhythms, who are less physically active or are more active later in the day are more likely to develop dementia or mild cognitive impairment than women who have a more robust circadian rhythm or are more physically active earlier in the day. That’s the finding of a new study in the latest issue of the Annals of Neurology.“We’ve known for some time that circadian rhythms, what people often refer to as the “body clock”, can have an impact on our brain and our ability to function normally,” says Greg Tranah, PhD., a scientist at the California Pacific Medical Center Research Institute – part of the Sutter Health network – and the lead author of the study. “What our findings suggest is...

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Flexible workplaces promote better health behavior and well-being

ΩA flexible workplace initiative improved employees' health behavior and well-being, including a rise in the amount and quality of sleep and better health management, according to a new study by University of Minnesota sociology professors Erin Kelly and Phyllis Moen, which appears in the December issue of the Journal of Health and Social Behavior."Our study shows that moving from viewing time at the office as a sign of productivity, to emphasizing actual results can create a work environment that fosters healthy behavior and well-being," says Moen. "This has important policy implications, suggesting that initiatives creating broad access to time flexibility encourage employees to take better care of themselves."Using longitudinal data collected from 608 employees of a white-collar organization...

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Soy is on top as a high-quality plant protein

Evaluation method supports soy protein as a high-quality protein similar to meat, eggs and dairyThe importance of protein in the human body is undeniable. However, the idea of what makes a protein a "quality protein" has not been as easy to determine. A new study from the Journal of Agriculture and Food Chemistry takes a closer look at the criteria for determining the quality of a protein.Traditional methods for determining protein quality have shown animal proteins such as milk and eggs to be high in quality. However, those who are interested in a plant-based diet, or diversifying their proteins, have a more difficult time determining which of their choices are high in quality. Testing methods have shown most plant proteins, such as pea protein, are lower in quality than animal-based proteins."Accurate...

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Physical Fitness Trumps Body Weight in Reducing Death Risks

ΩIf you maintain or improve your fitness level -- even if your body weight has not changed or increased -- you can reduce your risk of death, according to research reported in Circulation: Journal of the American Heart Association.In a study of 14,345 adult men, mostly white and middle or upper class, researchers found that: * Maintaining or improving fitness was associated with a lower death risk even after controlling for Body Mass Index (BMI) change. * Every unit of increased fitness (measured as MET, metabolic equivalent of task) over six years was associated with a 19 percent lower risk of heart disease and stroke-related deaths and a 15 percent lower risk of death from any cause. * Becoming less fit was linked to higher death risk, regardless of BMI changes. * BMI change...

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Reduce Heart Disease Risk: Eat Fish W/Omega 3 Fatty Acids

ΩYoung women may reduce their risk of developing cardiovascular disease simply by eating more fish rich in omega-3 fatty acids, researchers reported in Hypertension: Journal of the American Heart Association.In the first population-based study in women of childbearing age, those who rarely or never ate fish had 50 percent more cardiovascular problems over eight years than those who ate fish regularly. Compared to women who ate fish high in omega-3 weekly, the risk was 90 percent higher for those who rarely or never ate fish.Researchers used a Danish nationwide population based pregnancy cohort to examine whether or not eating more fish might reduce cardiovascular disease risk in the young women.About 49,000 women, 15-49 years old, median age of just under 30 years in early pregnancy -- were...

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The Scoop On the Dangers of Snow Shoveling

ΩUrban legend warns shoveling snow causes heart attacks, and the legend seems all too accurate, especially for male wintery excavators with a family history of premature cardiovascular disease. However, until recently this warning was based on anecdotal reports.Two of the most important cardiology associations in the US include snow -shoveling on their websites as a high risk physical activity, but all the citation references indicate that this warning was based one or two incidents."We thought that this evidence should not be enough to convince us that snow -shoveling is potentially dangerous, " says Adrian Baranchuk, a professor in Queen's School of Medicine and a cardiologist at Kingston General Hospital.Dr. Baranchuk and his team retrospectively reviewed KGH patient records from the two...

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Lower Antioxidants = Higher Skin-Cancer Rate In Males

Men are three times more likely than women to develop a common form of skin cancer but medical science doesn’t know why. A new study may provide part of the answer. Researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) have found that male mice had lower levels of an important skin antioxidant than female mice and higher levels of certain cancer-linked inflammatory cells. The antioxidant, a protein called catalase, inhibits skin cancer by mopping up hydrogen peroxide and other DNA-damaging reactive-oxygen compounds that form during exposure to ultraviolet B light (UVB), a common source of sunburn and cancer-causing skin damage. Studies by others have linked low catalase activity to...

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Vegetables, fruits, grains reduce stroke risk in women

ΩSwedish women who ate an antioxidant-rich diet had fewer strokes regardless of whether they had a previous history of cardiovascular disease, in a study reported in Stroke: Journal of the American Heart Association."Eating antioxidant-rich foods may reduce your risk of stroke by inhibiting oxidative stress and inflammation," said Susanne Rautiainen, M.Sc., the study's first author and Ph.D. student at the Karolinska Institutet in Sweden. "This means people should eat more foods such as fruits and vegetables that contribute to total antioxidant capacity."Oxidative stress is an imbalance between the production of cell-damaging free radicals and the body's ability to neutralize them. It leads to inflammation, blood vessel damage and stiffening.Antioxidants such as vitamins C and E, carotenoids...

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